Recombinant Human FGFR3 (mutated G697C) Protein (Active) (RMPP-00230623)
Cat. No.: RMPP-00230623
Category: Growth Factors & Cytokines
Research Area: Cardiovascular
INQUIRY
5 μg
Customer Size
Product Features
| Source | Insect cells |
|---|---|
| Purity | > 95% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Lyophilized |
| Applications | SDS-PAGE; ELISA |
| Key Features | Expression system: Insect cells; Purity: > 95% SDS-PAGE; Active: Yes; Suitable for: SDS-PAGE, ELISA |
Protein Information
| UniProt ID | P35968 |
|---|---|
| Molecular Weight | 105 kDa |
| Sequence | MESKALLAVALWFCVETRAASVGLTGDFLHPPKLSTQKDILTILANTTLQ ITCRGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDT GAYKCSYRDVDIASTVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVI PCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYAGMV FCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSAGEKLVLNCTA RTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVT KSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQV RIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTV ILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVY ANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGNKIEVTKN QYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPE ITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPV CKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKR HCLVKQLIILGMEASLGDRIAMP |
| Sequence Similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
| Protein Length | Protein fragment |
| Cellular Localization | Membrane. |
| Function | Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Involvement in Disease | Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involvingthis product localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. |
| Post-translational Modifications | Phosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. Constituents: 0.58% Sodium chloride, 0.49% MES This product is an active protein and may elicit a biological response in vivo, handle with caution. |
|---|
For research use only. Not for clinical use.
