Recombinant Human FGFR4 (mutated V550E) Protein (Active) (RMPP-00230617)
Cat. No.: RMPP-00230617
Category: Recombinant Protein
Research Area: Neuroscience
INQUIRY
5 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | > 90% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Form | Liquid |
| Applications | SDS-PAGE; Cell Differentiation |
| Key Features | Expression system: E.coli; Purity: > 90% SDS-PAGE; Suitable for: SDS-PAGE, CellDiff |
Protein Information
| UniProt ID | Q9UJU5 |
|---|---|
| Molecular Weight | 48 kDa |
| Sequence | 29 amino acid Tag-GEFTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGC DSPAGPPEL RLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGP GGDVGAPEADGCKGGVGGEEGGASG GGPGAGSGSAGGLAPSKPKNSLV KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREK FPAWQNS IRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFK RHQQEHL REQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAY SHPAAAAAAAAAAALQYPYALPP VAPVLPPAVPLLPSGELGRKAAAFG SQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPS ARPSFSIEN IIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAALMATH QPLSL SRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQLE ESGGGGSPGRRRRRRRRRRR |
| Sequence Similarities | Contains 1 fork-head DNA-binding domain. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. |
| Tissue Specificity | Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
| Function | Binds to the consensus sequence 5'-ATTTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. |
| Involvement in Disease | Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1). AIS1 is a disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at -20°C. pH: 8.00Constituent: 0.32% Tris HClContains a proprietary formulation of NaCl, EDTA, KCl, arginine, DTT and Glycerol. |
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For research use only. Not for clinical use.
