Recombinant Human GAS 6 Protein

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Recombinant Human GAS 6 Protein (RMPP-00230334)

Cat. No.: RMPP-00230334

Category: Recombinant Protein

Research Area: Immunology

INQUIRY 10 μg Customer Size

Product Features

Source	HEK 293 cells
Purity	> 90% SDS-PAGE.
Nature	Recombinant
Endotoxin Level	< 1.000 Eu/µg
Animal Free	No
Tags	Fc tag C-Terminus
Form	Lyophilized
Applications	Functional Studies; SDS-PAGE
Key Features	Expression system: HEK 293 cells; Purity: > 90% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Tags: Fc tag C-Terminus; Suitable for: Functional Studies, SDS-PAGE

Protein Information

UniProt ID	P25942
Molecular Weight	45 kDa including tags
Sequence	VTCSDKQ YLHDGQCCDL CQPGSRLTSH CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICGLKS RMR
Sequence Similarities	Contains 4 TNFR-Cys repeats.
Protein Length	Protein fragment
Cellular Localization	Secreted and Cell membrane.
Tissue Specificity	B-cells and in primary carcinomas.
Function	Receptor for TNFSF5/CD40LG.
Involvement in Disease	Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3); also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.

Storage & Shipping

Shipping and Storage	Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Please see notes section. pH: 7.4Constituents: 0.61% Tris, 0.75% Glycine, 3% Trehalose, Sodium chloride, L-ArginineNote: 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%. This product is an active protein and may elicit a biological response in vivo, handle with caution.

Shipping and Storage

Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Please see notes section.
pH: 7.4Constituents: 0.61% Tris, 0.75% Glycine, 3% Trehalose, Sodium chloride, L-ArginineNote: 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%.
This product is an active protein and may elicit a biological response in vivo, handle with caution.

For research use only. Not for clinical use.