Recombinant Human ProCollagen Type 1 alpha 1 Protein (RMPP-00230546)
Cat. No.: RMPP-00230546
Category: Recombinant Protein
Research Area: Stem Cells
INQUIRY
1 ml
5 ml
Product Features
| Source | E.coli |
|---|---|
| Purity | > 80% SDS-PAGE. |
| Nature | Recombinant |
| Animal Free | No |
| Tags | His tag N-Terminus |
| Form | Liquid |
| Applications | MS; SDS-PAGE |
| Key Features | Expression system: E.coli; Purity: > 80% SDS-PAGE; Tags: His tag N-Terminus; Suitable for: MS, SDS-PAGE |
Protein Information
| UniProt ID | Q9NSI8 |
|---|---|
| Molecular Weight | 44 kDa including tags |
| Sequence | MGSSHHHHHHSSGLVPRGSHMGSMLKRKPSNVSEKEKHQKPKRSSSFGNF DRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTM KKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMD SLYSGQSSSS GITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIK KGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRR SNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIK ESHLIELNIE NPDDRRRLLS AAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNS DNGKEDLESENLSDMVHKIIITEPSD |
| Sequence Similarities | Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain. |
| Protein Length | Full length protein |
| Cellular Localization | Nucleus. Cytoplasm. Cell projection > ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles. |
| Tissue Specificity | Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood. |
| Function | Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation. |
Storage & Shipping
| Shipping and Storage | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 8.00Constituents: 0.32% Tris HCl, 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.02% DTT |
|---|
For research use only. Not for clinical use.
