Recombinant Human TIE2 (mutated K855A) Protein (Tagged) (RMPP-00230709)
Cat. No.: RMPP-00230709
Category: Recombinant Protein
Research Area: Cardiovascular
INQUIRY
20 μg
Customer Size
Product Features
| Source | E.coli |
|---|---|
| Purity | > 95% SDS-PAGE. |
| Nature | Recombinant |
| Endotoxin Level | < 1.000 Eu/µg |
| Animal Free | Yes |
| Form | Lyophilized |
| Applications | SDS-PAGE; Functional Studies |
| Key Features | Expression system: E.coli; Purity: > 95% SDS-PAGE; Endotoxin level: < 1.000 Eu/µg; Active: Yes; Suitable for: SDS-PAGE, Functional Studies |
Protein Information
| UniProt ID | P40225 |
|---|---|
| Molecular Weight | 19 kDa |
| Sequence | SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF |
| Sequence Similarities | Belongs to the EPO/TPO family. |
| Protein Length | Protein fragment |
| Cellular Localization | Secreted. |
| Domain | Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal. |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Involvement in Disease | Defects in THPO are a cause of essential thrombocythemia (ET). ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. |
Storage & Shipping
| Shipping and Storage | Shipped at Room Temperature. Store at -20°C. Avoid freeze / thaw cycle. Constituent: 0.16% Sodium phosphate0.2 micron filtered This product is an active protein and may elicit a biological response in vivo, handle with caution. |
|---|
For research use only. Not for clinical use.
