Sheep Granulocyte Colony Stimulating Factor Receptor ELISA Kit (RMEK-0155741)
Cat. No.: RMEK-0155741
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Sheep |
|---|---|
| Assay Time | 1.5 h |
Target Information
| Target Symbol | GCSFR |
|---|---|
| UniProt ID | Q99062 |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. |
| Cellular Localization | [Isoform 2]: Secreted. Cell membrane; Single-pass type I membrane protein. |
| Domain | The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. |
| Post-transcriptional Modifications | N-glycosylated. |
| Involvement in Disease | Hereditary neutrophilia (NEUTROPHILIA): A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood. The disease is caused by variants affecting the gene represented in this entry. Neutropenia, severe congenital 7, autosomal recessive (SCN7): A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0. 5 x 10(9)/l and early onset of severe bacterial infections. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
|---|---|
| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
