ALS Stem Cell Therapy Development

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that affects nerve cells in the brain and spinal cord. Stem cell therapy has emerged as a promising area of research in the field of ALS. CD BioSciences offers stem cell therapy development services for amyotrophic lateral sclerosis to our global customers.

Introduction into Amyotrophic Lateral Sclerosis

ALS primarily targets the motor neurons, which are responsible for controlling voluntary muscle movement. As the disease progresses, these motor neurons gradually degenerate and die, leading to a loss of muscle control and eventual paralysis. This deterioration typically occurs in a relentless and asymmetric manner, affecting various regions of the body over time.

The exact causes of ALS remain largely unknown, although genetic factors are believed to play a role in a small percentage of cases. The majority of ALS cases, however, are considered sporadic, with no clear genetic or environmental triggers identified. Research suggests that a combination of genetic susceptibility, chemical imbalances within the nervous system, and environmental factors may contribute to the development of the disease.

Normal nerve cells Vs nerve cells with ALS

The symptoms of ALS can vary from person to person, but commonly include muscle weakness, twitching, and stiffness. As the disease progresses, individuals may experience difficulties with speech, swallowing, and breathing. ALS does not typically impair cognitive functions, such as memory or reasoning.

Stem Cell Therapy for Amyotrophic Lateral Sclerosis

Stem cell therapy has emerged as a promising area of research in the field of ALS. Stem cells are unique cells in the body that have the ability to differentiate into different types of cells and have the potential to repair and regenerate damaged tissues. In the context of ALS, stem cell therapy aims to replace the damaged motor neurons and provide support to the affected areas of the nervous system.

There are different types of stem cells that have been explored for ALS treatment, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). Each type has its own advantages and challenges.

Main types of stem cells and their potential to differentiate into various lineages (Sivandzade, et al., 2021)

Stem cell therapy for ALS involves the transplantation of stem cells into the affected areas of the central nervous system. The goal is to promote the survival of remaining motor neurons, stimulate the growth of new neurons, and modulate the inflammatory response. Theoretically, the basic strategy for treating ALS with stem cell therapy includes:

• Replacement of damaged/dead motor neurons
• Modulation of inflammation
• Promotion of neurotrophic factor expression

Our Services

CD BioSciences offers stem cell therapy development services for amyotrophic lateral sclerosis, based on our advanced technology and professional team.

Workflow of Our Service

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

1. Sivandzade, Farzane, and Luca Cucullo. "Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview." International journal of molecular sciences vol. 22,4 2153. 22 Feb. 2021.