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Stem Cell-Based Cardiovascular Disease Drug Screening

Stem Cell-Based Cardiovascular Disease Drug Screening

Cardiovascular diseases (CVDs) stand as a major global health challenge, encompassing a spectrum of conditions affecting the heart and blood vessels. In the pursuit of more effective treatments, stem cell-based drug screening services have emerged as a revolutionary approach to advance the understanding and management of cardiovascular diseases. CD BioSciences offers stem cell-based drug screening services for CVDs, based on out advanced technology and professional team.

Introduction into Cardiovascular Disease Therapy Development

CVDs are a leading cause of mortality worldwide, manifesting as a complex interplay of genetic, lifestyle, and environmental factors. These conditions, including coronary artery disease, heart failure, and hypertension, present diverse clinical symptoms and carry a substantial healthcare burden. The development of targeted therapies that address the underlying mechanisms of CVDs and improve patient outcomes is a crucial endeavor.

Heart Disease

Cutting-edge research in the field of cardiovascular diseases aims to understand the intricate mechanisms behind these conditions. Scientists and healthcare professionals are working tirelessly to develop novel drugs and therapies that can better address the root causes of CVDs, improve patient outcomes, and minimize adverse side effects. With the growing understanding of the disease's complexity, a revolutionary approach has emerged: stem cell-based drug screening.

How Stem Cells Work in CVDs Drug Screening

Stem cell-based drug screening represents a promising breakthrough in the battle against cardiovascular diseases. This innovative approach harnesses the regenerative potential of stem cells to model and study the intricate biology of the heart and blood vessels, providing researchers with a powerful tool to advance our understanding of CVDs. Cutting-edge research in this field involves the cultivation of pluripotent stem cells and their differentiation into specific cardiac cell types, such as cardiomyocytes, endothelial cells, and smooth muscle cells. These cells form the basis for accurate disease models and drug screening platforms.

iPSC-derived cardiac organoids for drug screening and toxicity testingiPSC-derived cardiac organoids for drug screening and toxicity testing (Mills, Richard J et al., 2019)

Human cardiomyocytes derived from induced pluripotent stem cells (iPSCs) are promising new tools for drug discovery and have already permitted drug testing and toxicology studies for a variety of human cardiac disorders.  These cardiac disorders, caused by a variety of mutations, include LQTS, CPVT, DCM, HCM, and arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C).

Our Services

CD BioSciences offers stem cell-based drug screening service based on our advanced technology and professional team. Our drug screening services are performed in cancers included but not limited as follows:

  • Angina Pectoris
  • Arrhythmias
  • Atherosclerosis
  • Brugada Syndrome
  • Cardiac Ischemia
  • Cardiomyopathy
  • Congenital Heart Defects
  • Coronary Artery Disease
  • Eisenmenger Syndrome
  • Heart Failure
  • Heart Attack
  • Heart Transplantation
  • Heart Valve Disorders
  • Hypertension
  • Hypertrophic Obstructive Cardiomyopathy
  • Hypoplastic Left Heart Syndrome
  • Infective Endocarditis
  • Inflammatory Heart Diseases
  • Kawasaki Disease
  • Long QT Syndrome
  • Mitral Valve Prolapse
  • Patent Ductus Arteriosus
  • Peripheral Artery Disease (PAD)
  • Pre-excitation Syndromes
  • Pulmonary Hypertension
  • Raynaud's Disease
  • Takotsubo Cardiomyopathy
  • Tetralogy of Fallot
  • Varicose Veins
  • Vascular Diseases
  • Venous Thromboembolism
  • Ventricular Septal Defect (VSD)
  • Wolff-Parkinson-White Syndrome

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

  1. Mills, Richard J et al. "Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway." Cell stem cell vol. 24,6 (2019): 895-907.e6.

For research use only, not for clinical use.