Nerve Tissue Development Service

Neural tissue engineering involves the combined use of biomaterials, cellular engineering, and drug delivery techniques with the goal of protecting, repairing, or regenerating cells and tissues of the nervous system. This strategy can be applied to repair damaged peripheral nerves when injury or disease occurs in the brain or spinal cord, or to improve the chronic function of implanted neural interfaces. CD BioSciences has launched a neural tissue development service.

Overview of Nerve Tissue Engineering

Nerve regeneration is a complex biological phenomenon. In the peripheral nervous system, nerves can regenerate on their own if the damage is minimal. Larger injuries must be treated surgically, usually with nerve grafts harvested from other parts of the body. Spinal cord injuries are more complex because there are factors in the body that inhibit repair. Unfortunately, a solution has not yet been found that can completely repair spinal cord injuries. In recent years, many efforts have been made to develop innovative neural tissue engineering approaches aimed at treating and improving nerve injuries.

• Main Elements for Nerve Tissue Engineering
  The factors required to repair peripheral nerves in tissue engineering include supporting cells, growth factors, catheters, and physical stimulation. Catheters direct nerve tissue regeneration by allowing cells to adhere and migrate. Physical stimuli, such as external ultrasound stimulation, laser, and electricity, are picked up by the cell's mechanosensors, leading to a cascade of cellular signaling pathways that ultimately affect cellular behavior. To promote nerve regeneration, the ideal nerve conduit should have specific properties, including biodegradability, biocompatibility, nutrient diffusion, controlled drug release capability, etc.

Nerve Tissue Regeneration (Jahromi, M. et al, 2019)

Challenges in Nerve Tissue Engineering

After years of research, neural tissue engineering has made some progress in scaffold materials, nerve growth-promoting substances, and seed cells. However, many problems are still faced. Improving the production process of scaffold materials so that they have structural and physiological properties similar to those of autologous structures can greatly improve the treatment effect of longer nerve defects. Enhancing the in vitro cellular living environment so that the regenerated nerve is in the optimal growth environment can promote the development of neural tissue engineering.

Applications of Tissue-engineered Nerve

Treatment of Diseases Caused by Central Nervous System Injury

The central nervous system includes the cerebral nerves and spinal cord. They show a series of pathological changes after injury, mainly including limb dysfunction, myelin disintegration, glial scar formation, destruction of the vascular system and inflammatory cell infiltration.

Treatment of Diseases Caused by Peripheral Nerve Injury

After peripheral nerve injury, retrograde degeneration of the nerve fibers at the proximal end of the injury occurs. Although peripheral nerve injury can be self-repairing to a certain extent, this regenerative capacity is far from meeting the needs of the organism.

Our Services

CD BioSciences provides nerve tissue development services. Based on our strong research team and abundant raw materials, we can provide various combinations to explore the preparation of artificial nerve tissues.

• Seed Cell Isolation & Culture
  We provide experiments for in vitro isolation, culture and identification of seed cells. Multiple growth factors are randomly combined in order to find the optimal culture condition.
• Nerve Tissue Engineering Scaffold Customization
  Scaffolds made with different raw materials can lead to different tissue growth results.

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

1. Jahromi, M. et al. (2019). The advance on nerve tissue engineering: from fabrication of nerve conduit to in vivo nerve regeneration assays. Journal of Tissue Engineering and Regenerative Medicine, 13(3).