Prostate Organoid Development Service

Prostate organoids are three-dimensional tissue cultures grown in a specific medium that resembles the prostate epithelium. The cultures form a spatial tissue structure similar to that of an organ and can be used for prostate research. Prostate organoids can be created from wild-type and genetically engineered mouse models, benign human tissue, and advanced prostate cancer. CD BioSciences has launched a prostate organoid development service to advance the prostate-related research process.

Culture of Prostate Organoid

Organoids are clusters of individual stem cells, progenitor cells, or clusters of cells of different lineages that spontaneously form a tissue-like structure in vivo under three-dimensional culture conditions. In general, the culture of BPH and prostate cancer-like organs starts with the isolation of individual cells. They are embedded in a matrix gel and cultured in plain serum-free medium supplemented with prostate-specific growth factors.

• Organoids Generated from Benign Prostate Epithelial

  The prostate epithelium is composed of luminal, basal, and neuroendocrine cells. The researchers found that basal cells were more productive in forming organoids, but luminal cells produced organoids closer to the prostate. This may indicate that basal cells have a self-renewal function, whereas luminal cells are able to differentiate into ducts and vesicles. To date, only benign epithelial prostate analogs have been successfully established. In addition, neuroendocrine epithelial cells have not been observed in benign prostate organoids.

• Prostate Tumor-derived Organoids

  Tumor-derived organoids are a promising tool for the future of precision oncology. Their potential as in vitro patient substitutes to facilitate drug screening, confirm therapeutic efficacy, and predict patient response is enormous. In addition, they can identify effective new drug combinations. However, current prostate tumor analogs are inefficient to establish and most are a narrow disease subtype.

Generation and Applications of Prostate Organoids (Gleave, A. M. et al., 2020)

Challenges in Prostate Organoids Development

Prostate organoids play an important role in the study of prostate biology and prostate cancer. However, there are several limitations associated with the model and improvements are needed. For example, organoid cultures lack important elements of the tumor micro-environment that have been shown to play a role in tumor progression and metastasis. In addition, the types and concentrations of biochemical signals, such as growth factors, are not identical in organoid cultures to those in vivo. Therefore, there is still a long way to go in the in vitro culture of prostate organoids.

Our Services

CD BioSciences offers prostate organoid development services. The prostate cancer organoid reshapes the tumor microenvironment and offers the possibility of developing personalized therapies by creating a model of the organoid that can be treated with drugs. For this reason, we have launched our prostate organoid development service. Based on our professional laboratory team, we can work with you to solve your prostate organoid-related research problems.

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service,please contact us.

Reference

1. Gleave, A. M. et al. (2020). A synopsis of prostate organoid methodologies, applications, and limitations. The Prostate. 80(6), 518-526.