Vascular Tissue Development Service

Clinical demand for bioengineered blood vessels continues to rise, but current vascular catheter options remain limited. New advances in tissue manufacturing and stem cell engineering are expected to provide new strategies for vascular tissue engineering. In response to this market demand, CD BioSciences has launched a vascular tissue development service.

Overview of Vascular Tissue Engineering

Ischemic diseases such as atherosclerotic cardiovascular disease remain one of the leading causes of mortality and morbidity worldwide. Currently, commonly used methods of vascular replacement include autografts, allogeneic vein grafts, and artificial material replacement. However, the lack of available healthy blood vessels makes it difficult to provide timely treatment for these diseases. Therefore, there is an urgent clinical need to repair damaged locally ischemic tissue, and tissue vascular regeneration provides an important solution to promote the growth of new vascular networks.

• Three Main Elements for Vascular Tissue Engineering
  Vascular tissue engineering mainly involves seed cells, extracellular matrix substitutes, and three-dimensional culture of tissue-engineered vessels. The seed cells include autologous vessel wall cells, embryonic stem cells and bone marrow mesenchymal stem cells, as well as numerous tissue cells such as endothelial cells, smooth muscle cells and fibroblasts. The vascular tissue microenvironment, which is composed of a three-dimensional scaffold and growth factors, facilitates cell adhesion, growth, and metabolism. The materials currently used in research applications are divided into natural biologic materials and synthetic materials, depending on their origin and properties.

Challenges in Vascular Tissue Engineering

Vascular tissue engineering is important not only for generating large vessels, but also for generating microvascular systems, such as supporting the engineering of isolated organs and tissues. Currently, engineered tissue vasculature is still in its infancy in the clinic, with most of these techniques still in preclinical studies involving animal models. With the development of in vitro microvasculature, the study of tissue-specific cellular interactions is becoming increasingly important. In addition, the resolution of host immune responses is also an important direction of research.

Applications of Tissue-engineered Vessel

Treatment of Diseases Caused by Vascular Insufficiency

Tissue-engineered vessel implants can be used to treat a variety of ischemic diseases caused by vascular insufficiency, such as coronary microvascular disease and diabetic wound healing, as well as traumatic injuries such as burns.

Organoid Vascularization

Organ-specific tissues can be created in vitro using microvasculature to increase their viability both before and after implantation.

Our Services

CD BioSciences provides vascular tissue development services. Based on our strong research team and abundant raw materials, we can provide various combinations to explore the preparation of artificial vascular tissues.

• Seed Cell Isolation & Culture
  We provide experiments for in vitro isolation, culture and identification of seed cells. Multiple growth factors are randomly combined in order to find the optimal culture condition.
• Vascular Tissue Engineering Scaffold Customization
  Scaffolds made with different raw materials can lead to different tissue growth results.

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.