Pancreatic Organoid Development Service
The pancreas is a hybrid endocrine and exocrine gland that plays a key role in digestion and metabolic homeostasis. Organoids derived from human fetal and adult pancreatic tissue have been used to study the development and repair of the pancreas. Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models and have enhanced the understanding of pancreatic cell biology. In this context, CD BioSciences has launched a service for the development of pancreatic organoid.
Types of Pancreatic Organoids
- Fetal Pancreatic Organoids
The key to understanding pancreatic development and regeneration lies in deciphering the molecular mechanisms of morphogenesis and cellular specialization. Scientists first used rodent fetal tissues for in vitro studies. However, this tissue is limited by short-term maintenance and multiple cell types, making it difficult to characterize and study true fetal pancreatic stem cells. Therefore, the use of primary fetal tissue is a valuable approach to study normal pancreatic morphogenesis and cellular signaling pathways.
- Adult Pancreatic Organoids
The human pancreatic duct shows the ability to expand and form 3D hollow structures in vitro, demonstrating its potential as a tool for regeneration studies. Pancreatic organoids derived from the adult pancreas can form hollow spheres. However, they are unable to form complex tip structures and do not have spontaneous endocrine cell differentiation, which fetal pancreatic organoids can.
Applications of Pancreatic Organoids
Pancreatic organoid is also a promising tool. It has been shown that human pancreatic-like organs are capable of long-term expansion under chemically-based conditions. This system can be used as a biological model for a healthy ductal pancreas or to develop models for ductal diseases such as cystic fibrosis. The organoid can also be constructed based on disease states and has been used to model different types of pancreatic cancer.
Because the organoid culture method allows for long-term culture of pancreatic cells, it is expected to be used to study the mechanisms of adult pancreatic regeneration.
This model can be used to study the effects of genetic mutations on the structure and behavior of iPSC pancreatic organoids. Pancreatic disease modeling using induced pluripotent stem cells from patients with monogenic disease in a 3D culture system can be used for studies of cystic fibrosis disease.
Organoid models have become a remarkable tool for in vitro drug screening. It can also be used to study the toxic effects of other compounds, such as alcohol, on pancreatic cells.
Our Services
CD BioSciences offers services for the development of pancreatic organoids. In addition to being used for pancreatic regeneration, pancreatic organoids are important models for disease modeling and new drug screening and evaluation. For this reason, we have launched our pancreatic organoid development service. Based on our professional laboratory team, we can work with you to solve your pancreatic organoid-related research problems.
As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service,please contact us.
For research use only, not for clinical use.
