Cornea Tissue Development Service
Many corneal diseases are currently treated with corneal transplants, artificial corneal implants or the use of corneal prostheses. However, the severe shortage of donor corneal tissue and the risk of infection transmission with artificial corneal implants necessitates the search for new methods of corneal regeneration. With the support of tissue engineering technology, CD BioSciences has launched a corneal tissue development service.
Overview of Cornea Tissue Engineering
Corneal trauma and ulcers, bacterial and viral infections, and hereditary diseases are the leading causes of corneal blindness. In the human body, the cornea is the most nerve-dense tissue and can sense a range of stimuli including light, heat and pain. Severely damaged corneas are often treated with corneal transplants, but insufficient donor corneas and subsequent immune rejection limit the treatment of related diseases. Tissue engineering of the cornea overcomes the current shortcomings of corneal transplantation and its application has been used to produce living corneal tissue of varying complexity.
- Process of Cornea Tissue Engineering
The key to tissue engineering of corneal reconstruction lies in healthy seed cells and appropriate scaffold material. The appropriate scaffold material is the key to successful construction of tissue-engineered corneas. Cells are isolated from human corneas and implanted on 3D scaffolds for culture. During this time, appropriate growth factors need to be added to stimulate the cells to grow into a multilayered cell-like stroma. Then, neuroblastoma cells are inoculated on top of the stromal cells to start neuronal cell differentiation. This culminates in a three-dimensional in vitro model of corneal stromal cells and differentiated neuronal cells.
Cornea Tissue Engineering (Rabab, et al. ,2018)
Applications of Tissue-engineered Cornea
The construction of tissue-engineered corneas with good biological activity and capable of meeting certain physiological functional requirements has practical clinical applications. It solves the problem of insufficient donor corneas and brings a new approach to the treatment of corneal diseases.
The pharmaceutical and cosmetic industries are driving the demand for in vitro preclinical corneal tissue models in order to reduce the number of associated animal tests. As a result, more complex in vitro models need to be developed to better match the physiological needs of humans.
Our Services
CD BioSciences offers corneal tissue development services, including but not limited to seed cell processing, provision of exogenous stimulation conditions, and scaffold material screening. Based on our professional laboratory team, we can work with you to solve your artificial corneal development problems.
- Seed Cell Isolation & Culture
We provide experiments for in vitro isolation, culture and identification of seed cells. Multiple growth factors are randomly combined in order to find the optimal culture condition. - Corneal Tissue Engineering Scaffold Customization
Scaffolds made with different raw materials can lead to different tissue growth results.
As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.
Reference
- Rabab, et al. (2018). Corneal tissue engineering: an in vitro model of the stromal-nerve interactions of the human cornea. Journal of visualized experiments: JoVE.
For research use only, not for clinical use.
