Diabetes Stem Cell Therapy Development

Stem cell therapy is a type of treatment that uses stem cells to repair or replace damaged or diseased cells in the body. In the context of diabetes, stem cell therapy has the potential to restore insulin-producing beta cells in the pancreas, which are destroyed in individuals with type 1 diabetes, and improve insulin sensitivity in individuals with type 2 diabetes. CD BioSciences has launched a stem cell therapy development service for diabetes, dedicated to advancing the treatment of this disease.

Overview of Diabetes

Diabetes is a chronic condition that affects how the body uses blood sugar (glucose), which is the body's main source of energy. There are three main types of diabetes: Type 1 diabetes, Type 2 diabetes and gestational diabetes.

Type 1 diabetes	Type 2 diabetes	Gestational diabetes
The immune system attacks and destroys the cells in the pancreas that produce insulin, a hormone that regulates blood sugar levels. As a result, people with Type 1 diabetes require insulin injections or an insulin pump to manage their blood sugar levels.	It occurs when the body becomes resistant to insulin or does not produce enough insulin to maintain normal blood sugar levels. Risk factors for Type 2 diabetes include obesity, a sedentary lifestyle, high blood pressure, and family history.	It is caused by hormones produced during pregnancy that can make the body resistant to insulin. It typically goes away after delivery, but women who have had gestational diabetes are at an increased risk of developing Type 2 diabetes later in life.

Symptoms of diabetes can include increased thirst and hunger, frequent urination, blurry vision, slow healing wounds, and fatigue. If left untreated, diabetes can lead to serious complications such as heart disease, nerve damage, kidney damage, and vision loss.

Stem Cell Therapy of Diabetes

Stem cells are cells that have the ability to develop into many different types of cells in the body. Stem cell therapy for diabetes involves using stem cells to regenerate or replace damaged cells in the pancreas that produce insulin.

Stem cells with the potential to develop into insulin-secreting cells (Pan, Gui et al., 2019)

Several types of stem cells have been studied for their potential use in diabetes treatment, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells such as mesenchymal stem cells and hematopoietic stem cells. Following is comparison between different stem cells that are used in diabetes treatment.

SC Type	Advantages	Disadvantages
ESCs	Pluripotent differentiation capacity with unlimited multiplicative ability	Ethical constraints Highest risk for teratoma formation Elicits an autoimmune response
iPSCs	β-cell replicates can be generated without ethical controversy Easily accessible stem cell source of IPCs	Mutagenic potential of some reprogramming methods Barriers to long-term transplant viability and functionality Risk for teratoma formation Risk of express more than one hormone Immature non-glucose-responsive phenotype
MSCs	Improved β-cell function through immunomodulation Low risk of autoimmune response Lower oncogenic risk	Incomplete and temporary therapeutic effect Requires chronic administration and adjunct therapy
Pancreatic Adult SC	Differentiation to structures that resemble islets Multipotency and clonogenic potential	Specific markers for isolation and identification of these cell population are needed
Hepatic SC	Improved β-cell function using small molecules	Low efficiency Nonselective effect

Our Services

CD BioSciences offers stem cell therapy development services of diabetes. Based on our professional laboratory team, we can contribute to the development of stem cell therapy for diabetes. Our services are included but not limited as follows:

Stem cells with the potential to develop into insulin-secreting cells

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

Pan, Gui et al. "Examining the therapeutic potential of various stem cell sources for differentiation into insulin-producing cells to treat diabetes." Annales d'endocrinologie vol. 80,1 (2019): 47-53.

For research use only, not for clinical use.