Heart Failure Stem Cell Therapy Development

Heart failure (HF) is a medical condition that occurs when the heart is unable to pump enough blood to meet the body's demands. It can result from a variety of underlying causes, such as high blood pressure, coronary artery disease, heart attack, heart valve disease, or congenital heart defects. Stem cell therapy is considered as one of the most promising approaches for HF treatment. CD BioSciences provide stem cell therapy development services for heart failure, dedicated to advancing the treatment of this disease.

Overview of Heart Failure

Heart failure (HF) is a common, expensive, lethal, and disabling condition that has become global epidemic drastically cutting short longevity and compromises quality of life. Heart failure is a medical condition that occurs when the heart is unable to pump enough blood to meet the body's demands. It can result from a variety of underlying causes, such as high blood pressure, coronary artery disease, heart attack, heart valve disease, or congenital heart defects.

When the heart fails to pump effectively, blood may back up into the lungs, causing shortness of breath, or it may accumulate in the lower extremities, causing swelling in the legs and ankles. Other symptoms of heart failure may include fatigue, weakness, coughing, wheezing, rapid or irregular heartbeat, and difficulty exercising.

Schematic factors for the development of HF (Riehle, Christian, et al., 2019)

Stem Cell Therapy for Heart Failure

Stem cell transplantation is considered to be a promising approach for the treatment of HF. Many types of cells, including pluripotent stem cells and adult tissue-resident stem cells, have been proposed and tested in experimental and clinical studies. Although myocardial differentiation of MSCs appears to be insignificant in vivo, MSCs are capable of secreting a range of repair molecules including cytokines, chemokines, growth factors, microRNAs and exosomes. These beneficial secreted proteomes have anti-inflammatory, neovascularization, anti-fibrotic, and anti-apoptotic effects, thereby repairing damaged myocardium.

Stem cells used in cardiac regenerative therapy (Nair, Nandini, et al., 2020)

Key factors that make stem cell transplantation an ideal donor for HF cell therapy include:

• Safety when injected in vivo.
• Absence of ethical issues.
• Ability to induce myocardial repair and/or regeneration.
• Ability to treat multiple HF types, including ischemic and non-ischemic diseases.
• Availability of high quality, homogeneous cells produced in large quantities.
• Absence of immunosuppressive reagents using allogeneic cells.

Our Services

In the context of heart failure, stem cell therapy has the potential to regenerate damaged heart tissue and improve heart function. Stem cell therapy is a promising avenue for heart failure treatment, more research is needed to fully understand its safety and effectiveness. CD BioSciences offers stem cell therapy development services of heart failure. Based on our professional team and edge-cutting technologies, we can contribute to the development of stem cell therapy for heart failure.

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

References

1. Riehle, Christian, et al. "Small animal models of heart failure." Cardiovascular research vol. 115,13 (2019): 1838-1849.
2. Nair, Nandini, et al. "Stem cell therapy in heart failure: Where do we stand today?." Biochimica et biophysica acta. Molecular basis of disease vol. 1866,4 (2020): 165489.