Pulmonary Organoid Development Service
Lung stem cells can be used in the culture of pulmonary organoid. Studies have shown that pulmonary organoids are currently the closest model to the human lung system, and in vitro lung models represented by pulmonary organoids have become more accessible tools for studying lung development, function and disease pathology. For this reason, CD BioSciences has launched pulmonary organoid development service.
Overview of Pulmonary Organoid
The lung is a complex organ composed of a variety of epithelial, immune, endothelial and mesenchymal cells. It is composed of more than 40 different cell types that support the complex 3-dimensional structure required for efficient lung function. Pulmonary organoid displays features of the human airway such as alveolar structure, mucus secretion, cilia beating and regeneration. Pulmonary organoid is essentially a 3D tissue-engineered miniature lung that encapsulates the morphological and functional characteristics of the airway. By developing these structures and functions, the organoid mimics the physiological or pathological environment of the body.
Pulmonary Organoids of Multiple Cellular Origin
Airway basal cells were first successfully used to culture pulmonary organoids. Since then, pulmonary organoids have been successfully grown from adult stem cells, human pluripotent stem cells including embryonic stem cells and induced pluripotent stem cells. Human bronchospheres from p63pos NGFRpos Integrin α6pos airway basal cells are mainly composed of basal cells and two major differentiated cells, goblet cells and ciliated cells. Organoids derived from Sox2pos or Integrin β4pos distal airway cells display alveolar or bronchiolar differentiation with or without the supporting cells. It was shown that hPSC-derived pulmonary organoids produce more mature airway epithelial cells after transplantation into mice.
Applications of Pulmonary Organoids
Organoid has important applications in lung regeneration and disease research, including pulmonary fibrosis, airway diseases, cancer and infectious diseases. Given that human lung organoids faithfully mimic viral infections in living organisms, it is also possible to use human lung organoids for the study of SARS-CoV-2 infections.
In vitro lung modeling is an easily accessible way to study lung development, function, and disease pathology. The pulmonary organoid is precisely an accurate in vitro system that outlines the structural features of the native lung.
Pulmonary organoids share similar physiological structure and functional properties of the human pulmonary airways. It helps to study the repair of lung injury, biogenic mechanisms and phenotypic changes of lung diseases.
Since pulmonary organoids are hollow with internal lumen and cavities, they are easily penetrated by light. This makes them suitable for confocal imaging, allowing quantitative characterization of cell contents, live-dead assessment and scoring of specifically labeled cells.
Our Services
CD BioSciences offers pulmonary organoid development services. Pulmonary organoids are able to accurately reproduce the interactions between the human lung environment and cells, and thus their re-basic research and disease studies have important uses. For this purpose, we have introduced the following services. Based on our professional laboratory team, we can work with you to solve your pulmonary organoid-related research problems.
As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service,please contact us.
For research use only, not for clinical use.
