Brain Organoid Development Service
Brain organoids are three-dimensional aggregates generated from pluripotent stem cells with cell types and cell structures similar to those of the human embryonic brain. Thus, providing a unique opportunity to mimic the development and function of the human brain, they are able to satisfy relevant researchers conducting experiments. In this prospect, CD BioSciences offers brain organoid development service to fuel brain-related research.
Overview of Brain Organoids
In recent years, the cultivation and study of brain organoids has been a major hot topic in the field of neuroscience. Scientists have already induced human brain organoids derived from pluripotent stem cells into different brain regions with the help of different combinations of small molecules and growth factors. Region-specific human brain organoids have been and successfully obtained, including the midbrain, hippocampus, thalamus, cerebellum, striatum, etc. In addition, the application of different biomaterials, such as porous rotating bioreactors, polymer-formed microfilaments, etc., has also successfully guided the formation of human brain organoids.
Interactions Between Neural Lineage Cells in Organoids
The investigation of cellular interactions in brain organoids requires an understanding of human brain development. To create various cell types and go forth to the proper sites, neuroepithelial cells go through many differentiation processes.
Apical radial glial cells multiply early in neurogenesis to create the progenitor pool. After that, they transition to asymmetric divisions, producing either different types of neural progenitor cells, like the subventricular zone basal progenitor cells, or neurons that move out from the ventricular zone and settle in the newly formed cortical plate.
When xenotransplanted into the adult mouse cortex, organoid-derived neurons interacted not only with host neurons but also with other organoid-derived neurons, demonstrating synapse development between host neurons and organoid neurons. It has been demonstrated that organoid-derived neurons in hosts can develop, mature, and extend axonal projections after transplantation.
With a variety of neuronal connections that impact neuronal development, maturation, synapse formation, and survival, astrocytes play a crucial role in the blood-brain barrier. In a co-culture setup with murine embryonic cortical neurons, brain organoid-derived astrocytes improved neurite development and survival of mouse embryonic cortical neurons.
Oligocortical spheroids revealed concentric, but often unorganized, wrapping of human axons with multiple layers of uncompacted myelin. With further maturation and deep and superficial layer-marked neuron populations organized into distinct cortical layers with MYRF+ oligodendrocytes present at both layers. These axons formed distinct layers adjacent to deep-layer neurons, and oligodendrocyte processes were co-localized with neurofilament-expressing neuronal axons.
Applications of brain organoids. (Xuyu, Qian.et al., 2019)
Our Services
CD BioSciences offers brain organoid development services. brain organoids are important models for neurophysiological and disease research. For this reason, we have introduced brain organoid development services. Based on our professional laboratory team, we can work with you to solve your brain organoid-related research problems.
As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service,please contact us.
References
- Xuyu, Qian. et al. (2019). Brain organoids: advances, applications and challenges. Development.
- Oluwafemi Solomon Agboola. et al. (2021). Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro. Stem Cell Research & Therapy. 12(1)：430.
For research use only, not for clinical use.
