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Parkinson's Disease Stem Cell Therapy Development

Parkinson's Disease Stem Cell Therapy Development

Parkinson's Disease is a chronic and progressive neurological disorder that affects the central nervous system. Stem cell therapy are potential treatment for Parkinson's disease. Here, CD BioSciences aims to provide our global customers with a comprehensive understanding of Parkinson's Disease, the potential of stem cell therapy in its treatment, and the services we offer in this exciting field of medical advancement.

Introduction into Parkinson's Disease

Parkinson's Disease is a neurodegenerative disorder that affects millions of people worldwide. It is characterized by the progressive loss of dopamine-producing cells in a specific region of the brain called the substantia nigra. Dopamine is a neurotransmitter that plays a crucial role in facilitating smooth and coordinated movement. When the dopamine-producing cells are damaged or destroyed, it leads to a depletion of dopamine levels in the brain. As a result, individuals with Parkinson's Disease experience a range of motor symptoms, including tremors (involuntary shaking), muscle rigidity, bradykinesia (slowness of movement), and postural instability.

In addition to motor symptoms, Parkinson's Disease can also cause non-motor symptoms such as cognitive impairment, depression, sleep disturbances, and autonomic dysfunction. These symptoms can significantly impact a person's daily functioning and quality of life.

Fig1. Symptoms of Parkinsons Disease

The exact cause of Parkinson's Disease is still unknown, but research suggests that it involves a combination of genetic and environmental factors. While most cases are sporadic, occurring without a clear familial link, approximately 10% of cases are considered to be hereditary. Parkinson's Disease predominantly affects older individuals, with the average age of onset being around 60 years. However, early-onset Parkinson's can occur in individuals younger than 50. Men are slightly more likely to develop the condition than women.

While current treatments such as medication, physiotherapy, and deep brain stimulation can help manage symptoms to some extent, they do not provide a cure or halt the disease progression. This is where stem cell therapy offers promising prospects.

Stem Cell Therapy for Parkinson's Disease

Stem cells are unique cells in our bodies that possess the remarkable ability to differentiate into various specialized cell types. Stem cell therapy involves the transplantation of these cells into the affected areas of the brain to replace the damaged or lost dopamine-producing cells.

Fig2. SCs in Parkinson's diseaseSCs in Parkinson's disease (Zayed, Mohamed A et al. 2022)

There are different types of stem cells used in Parkinson's Disease treatment, including embryonic stem cells, induced pluripotent stem cells (iPSCs), and adult stem cells. Each type has its advantages and considerations, and the choice depends on various factors, such as availability, ethical considerations, and effectiveness.

Stem cell therapy holds great potential for Parkinson's Disease for several reasons. First, stem cells can differentiate into dopamine-producing neurons, replenishing the depleted cell population. Second, they can promote neuroprotection and repair by releasing various growth factors and anti-inflammatory molecules. Finally, stem cells may integrate into the existing neural networks, restoring proper communication within the brain.

Our Services

CD BioSciences offers stem cell therapy development services for Parkinson's Disease, based on our advanced technology and professional team. Our services are provided in Parkinson's disease included but not limited as follows:

Fig3. Workflow

Disease Modeling
Stem Cell Therapy Development
Stem Cell-based Drug Development
Drug Safety Assessment

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

  1. Zayed, Mohamed A et al. "Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders." Cells vol. 11,21 3476. 2 Nov. 2022.

For research use only, not for clinical use.