Heart Valve Tissue Development Service

Despite recent medical and surgical advances, many people continue to suffer from cardiovascular disease. In the field of cardiac surgery, heart valve replacement is the mainstay of treatment for valvular heart lesions. Heart valve tissue engineering is a new approach based on restoring or replacing damaged tissue with stents, cells and growth factors. With the support of tissue engineering technology, CD BioSciences has launched a heart valve tissue development service.

Overview of Heart Valve Tissue Engineering

Surgical heart valve replacement is one of the most commonly performed procedures to improve quality of life and reduce mortality. Repair of congenital malformations requires very small valve sizes, and due to this limitation, it is difficult to provide enough heart valves. Currently, prosthetic devices available for valve replacement are mechanical valves, bioprosthetic heart valves, and cryopreserved homograft valves, but all have various problems in clinical practice. As a result, these limitations have led to the emergence of a new concept known as heart valve tissue engineering.

• Main Elements for Heart Valve Tissue Engineering
  The three major elements of tissue-engineered heart valves are seed cells, scaffold material, and cell implantation. Mesenchymal stem cells, fibroblasts, myofibroblasts, and umbilical cord blood stem cells are used for in vitro tissue engineering of heart valves. Tissue-engineered heart valve scaffold materials include natural scaffold materials and synthetic materials. Cellular implantation includes static bioreactors and dynamic bioreactors. Among them, the static growing method is easy to operate and requires less conditions for culture. Dynamic implantation is the use of bioreactors to grow cells with scaffold materials, which requires high conditions but is more suitable for in vivo implantation.

Heart Valve Tissue Engineering (Safieh Boroumand. et al. ,2018)

Applications of Tissue-engineered Heart Valve

Currently, tissue-engineered heart valves hold great promise for clinical use. Heart valve disease is a growing problem, and the need for heart valve replacement will increase dramatically in the future. Existing mechanical valves may cause bleeding and thromboembolism, whereas biologic valves are prone to fibrosis, calcification, degeneration, and immunologic complications. Tissue-engineered heart valves are a potential, ideal artificial heart valve. Its near-normal physiological state lays the foundation for its clinical application.

Our Services

CD BioSciences offers heart valve tissue development services including seed cell culture, growth factor combination screening and scaffold customization. Based on our wide range of artificial valve tissue materials, we can provide a variety of combinations for exploring artificial valve tissue preparation methods.

• Seed Cell Isolation & Culture
  We provide experiments for in vitro isolation, culture and identification of seed cells. Multiple growth factors are randomly combined in order to find the optimal culture condition.
• Heart Valve Tissue Engineering Scaffold Customization
  Scaffolds made with different raw materials can lead to different tissue growth results.

As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. CD BioSciences is committed to providing professional and efficient service to our customers around the world. If you are interested in our service, please contact us.

Reference

1. Boroumand, S. et al. (2018). Heart valve tissue engineering: an overview of heart valve decellularization processes. Regenerative Medicine, 41.