Anti-14-3-3 sigma/SFN Antibody - BSA and Azide free (Capture) (RMAB-0252362)
Cat. No.: RMAB-0252362
Category: Antibody Pair
INQUIRY
100 μg
1 mg
Rabbit monoclonal to 14-3-3 sigma/SFN - BSA and Azide free (Capture)
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20647-263 |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | Sandwich ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to 14-3-3 sigma/SFN - BSA and Azide free (Capture); Suitable for: Sandwich ELISA; Reacts with: Human |
Target Information
| Target Symbol | SFN |
|---|---|
| Target Name | 14-3-3 protein sigma |
| UniProt ID | P31947 |
| Cellular Localization | Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.p53-regulated inhibitor of G2/M progression. |
| Post-translational Modifications | Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. |
| Sequence Similarities | Belongs to the 14-3-3 family. |
Storage & Shipping
| Storage Buffer | Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C. |
For research use only. Not for clinical use.
