Anti-160 kD Neurofilament Medium Antibody - BSA and Azide free (RMAB-0250027)
Cat. No.: RMAB-0250027
Category: Primary Antibodies
INQUIRY
100 μg
1 mg
Rabbit monoclonal to 160 kD Neurofilament Medium - BSA and Azide free
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR23510-76 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, IP, IHC-P, ELISA, IHC-Fr, Flow Cyt (Intra), ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to 160 kD Neurofilament Medium - BSA and Azide free; Suitable for: WB, IP, IHC-P, ELISA, IHC-Fr, Flow Cyt (Intra), ICC/IF; Knockout validated; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | NEFM |
|---|---|
| Target Name | Neurofilament medium polypeptide |
| UniProt ID | P07197 |
| Function | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. |
| Post-translational Modifications | There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C. |
For research use only. Not for clinical use.
