Anti-Activin Receptor Type IA Antibody (RMAB-0250039)
Cat. No.: RMAB-0250039
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Activin Receptor Type IA
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 2E2C11 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment corresponding to Human Activin Receptor Type IA aa 1-15. Expressed in E.coli. |
| Applications | WB, IHC-P, Flow Cyt, ICC/IF |
| Key Features | Mouse monoclonal to Activin Receptor Type IA; Suitable for: WB, IHC-P, Flow Cyt, ICC/IF; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | ACVR1 |
|---|---|
| Target Name | Activin receptor type-1 |
| UniProt ID | Q04771 |
| Cellular Localization | Membrane. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. |
| Involvement in Disease | Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP). FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible. |
| Sequence Similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | Preservative: 0.05% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
