Anti-alpha smooth muscle Actin Antibody (RMAB-0250059)
Cat. No.: RMAB-0250059
Category: Primary Antibodies
INQUIRY
100 μg
1 mg
Mouse monoclonal to alpha smooth muscle Actin
Product Features
| Isotype | IgG2a |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 1A4 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide corresponding to Human alpha smooth muscle Actin (N terminal). |
| Applications | ICC/IF, Flow Cyt (Intra), IHC-P, WB |
| Key Features | Mouse monoclonal to alpha smooth muscle Actin; Suitable for: ICC/IF, Flow Cyt (Intra), IHC-P, WB; Knockout validated; Reacts with: Mouse, Rat, Human; Isotype: IgG2a |
Target Information
| Target Symbol | ACTA2 |
|---|---|
| Target Name | Actin, aortic smooth muscle |
| UniProt ID | P62736 |
| Cellular Localization | Cytoplasm > cytoskeleton. |
| Function | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Involvement in Disease | Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6). AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. |
| Sequence Similarities | Belongs to the actin family. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituents: PBS, 6.97% L-Arginine |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
