Anti-Angiotensin Converting Enzyme 1 Antibody (RMAB-0250066)
Cat. No.: RMAB-0250066
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Angiotensin Converting Enzyme 1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR22250-204 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Rat, Recombinant fragment |
| Immunogen | Recombinant fragment within Mouse Angiotensin Converting Enzyme 1 aa 6-125. The exact sequence is proprietary. |
| Applications | WB, IHC-P, IHC-Fr, ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Angiotensin Converting Enzyme 1; Suitable for: WB, IHC-P, IHC-Fr, ELISA; Reacts with: Mouse, Rat, Recombinant fragment |
Target Information
| Target Symbol | ACE |
|---|---|
| Target Name | Angiotensin-converting enzyme |
| UniProt ID | P12821 |
| Cellular Localization | Secreted and Cell membrane. |
| Function | Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. |
| Involvement in Disease | Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Disease susceptibility is associated with variations affecting the gene represented in this entry.Renal tubular dysgenesis (RTD): Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). The disease is caused by mutations affecting the gene represented in this entry.Microvascular complications of diabetes 3 (MVCD3): Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Disease susceptibility is associated with variations affecting the gene represented in this entry.Intracerebral hemorrhage (ICH): A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Disease susceptibility is associated with variations affecting the gene represented in this entry. |
| Post-translational Modifications | Phosphorylated by CK2 on Ser-1299; which allows membrane retention. |
| Sequence Similarities | Belongs to the peptidase M2 family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
