Anti-Axin 2 Antibody - BSA and Azide free (Detector) (RMAB-0252326)
Cat. No.: RMAB-0252326
Category: Antibody Pair
INQUIRY
100 μg
1 mg
Rabbit monoclonal to Axin 2 - BSA and Azide free (Detector)
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | YCA-R23454-50 H2L2 |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | Sandwich ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Axin 2 - BSA and Azide free (Detector); Suitable for: Sandwich ELISA; Reacts with: Human |
Target Information
| Target Symbol | AXIN2 |
|---|---|
| Target Name | Axin-2 |
| UniProt ID | Q9Y2T1 |
| Cellular Localization | Cytoplasm. |
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Involvement in Disease | Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. |
| Post-translational Modifications | Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. |
| Domain | The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2. |
| Sequence Similarities | Contains 1 DIX domain. Contains 1 RGS domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C. Do Not Freeze. |
For research use only. Not for clinical use.
