Anti-BCRP/ABCG2 Antibody (RMAB-0250080)
Cat. No.: RMAB-0250080
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to BCRP/ABCG2
Product Features
Isotype | IgG |
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Clonality | Monoclonal |
Host Species | Rabbit |
Clone Number | EPR21122 |
Form | Liquid |
Purity | Protein A purified |
Species Reactivity | Human |
Immunogen | Recombinant fragment. |
Applications | Flow Cyt, IHC-P, ICC/IF |
Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to BCRP/ABCG2; Suitable for: Flow Cyt, IHC-P, ICC/IF; Reacts with: Human |
Target Information
Target Symbol | ABCG2 |
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Target Name | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
UniProt ID | Q9UNQ0 |
Cellular Localization | Cell membrane. |
Function | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. |
Post-translational Modifications | Glycosylation-deficient ABCG2 is normally expressed and functional. |
Sequence Similarities | Belongs to the This antibody transporter superfamily. This antibody family. Eye pigment precursor importer (TC 3.A.1.24) subfamily. Contains 1 This antibody transmembrane type-2 domain. Contains 1 This antibody transporter domain. |
Storage & Shipping
Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol, 0.05% BSA |
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Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.