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Anti-BCRP/ABCG2 Antibody (RMAB-0250080)

Cat. No.: RMAB-0250080

Category: Primary Antibodies

INQUIRY 100 μL Customer Size
Rabbit monoclonal to BCRP/ABCG2

Product Features

Isotype IgG
Clonality Monoclonal
Host Species Rabbit
Clone Number EPR21122
Form Liquid
Purity Protein A purified
Species Reactivity Human
Immunogen Recombinant fragment.
Applications Flow Cyt, IHC-P, ICC/IF
Key Features Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to BCRP/ABCG2; Suitable for: Flow Cyt, IHC-P, ICC/IF; Reacts with: Human

Target Information

Target Symbol ABCG2
Target Name Broad substrate specificity ATP-binding cassette transporter ABCG2
UniProt ID Q9UNQ0
Cellular Localization Cell membrane.
Function Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Post-translational Modifications Glycosylation-deficient ABCG2 is normally expressed and functional.
Sequence Similarities Belongs to the This antibody transporter superfamily. This antibody family. Eye pigment precursor importer (TC 3.A.1.24) subfamily. Contains 1 This antibody transmembrane type-2 domain. Contains 1 This antibody transporter domain.

Storage & Shipping

Storage Buffer pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol, 0.05% BSA
Storage & Shipping Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

For research use only. Not for clinical use.