Anti-BMP4 Antibody - BSA and Azide free (Detector) (RMAB-0252322)
Cat. No.: RMAB-0252322
Category: Antibody Pair
INQUIRY
100 μg
1 mg
Rabbit monoclonal to BMP4 - BSA and Azide free (Detector)
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR18235-122 |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | Sandwich ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to BMP4 - BSA and Azide free (Detector); Suitable for: Sandwich ELISA; Reacts with: Human |
Target Information
| Target Symbol | BMP4 |
|---|---|
| Target Name | Bone morphogenetic protein 4 |
| UniProt ID | P12644 |
| Cellular Localization | Secreted > extracellular space > extracellular matrix. |
| Function | Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. |
| Involvement in Disease | Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6); also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateralof ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocularities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11). Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero. |
| Sequence Similarities | Belongs to the TGF-beta family. |
Storage & Shipping
| Storage Buffer | Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C. |
For research use only. Not for clinical use.
