Anti-CD105 Antibody (RMAB-0250160)
Cat. No.: RMAB-0250160
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Mouse monoclonal to CD105
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 105C02 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human |
| Immunogen | Full length protein corresponding to CD15. Purified GP16 from cell membrane glycoproteins of fresh non-T/non-B acute lymphoblastic leukemia cells. |
| Applications | WB |
| Key Features | Mouse monoclonal to CD105; Suitable for: WB; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | ENG |
|---|---|
| Target Name | Endoglin |
| UniProt ID | P17813 |
| Cellular Localization | Membrane. |
| Function | Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. |
| Involvement in Disease | Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1); also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.1% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
