Anti-CD19 Rabbit Monoclonal Antibody (RMAB-0251470)
Cat. No.: RMAB-0251470
Category: Primary Antibodies
Research Area: Immunology, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-CD19 Rabbit Monoclonal Antibody. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human CD19. |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
Target Information
| Target Symbol | CD19 |
|---|---|
| Target Name | B-lymphocyte antigen CD19 |
| UniProt ID | P15391 |
| Function | Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
| Involvement in Disease | Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3); also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. |
| Post-translational Modifications | Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. |
| Sequence Similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
