Anti-CD276 Antibody (RMAB-0250272)
Cat. No.: RMAB-0250272
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Mouse monoclonal to CD276
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | MM0104-20J12 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment corresponding to the extracellular domain of Human CD276 |
| Applications | Flow Cyt, IHC-P |
| Key Features | Mouse monoclonal to CD276; Suitable for: Flow Cyt, IHC-P; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | CD276 |
|---|---|
| Target Name | CD276 antigen |
| UniProt ID | Q5ZPR3 |
| Cellular Localization | Membrane. |
| Function | May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. |
| Sequence Similarities | Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 Ig-like V-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
