Anti-CD41 ITGA2B Rabbit Monoclonal Antibody (RMAB-0251372)
Cat. No.: RMAB-0251372
Category: Primary Antibodies
Research Area: Cardiovascular, Immunology, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-CD41 ITGA2B Rabbit Monoclonal Antibody. Tested in WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
Target Information
| Target Symbol | ITGA2B |
|---|---|
| Target Name | Integrin alpha-IIb |
| UniProt ID | P08514 |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Involvement in Disease | Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT); also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-2% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (6-1%) expression of dysfunctional receptors. |
| Sequence Similarities | Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
