Anti-CD44 Antibody (RMAB-0250369)
Cat. No.: RMAB-0250369
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to CD44
Product Features
Isotype | IgG2a |
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Clonality | Monoclonal |
Host Species | Mouse |
Clone Number | Hermes-3 |
Form | Liquid |
Purity | Protein A purified |
Species Reactivity | Human |
Immunogen | Recombinant fragment corresponding to Human CD44. |
Applications | IP, ICC/IF, ELISA, WB, IHC-P |
Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to CD44; Suitable for: IP, ICC/IF, ELISA, WB, IHC-P; Knockout validated; Reacts with: Human |
Target Information
Target Symbol | CD44 |
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Target Name | CD44 antigen |
UniProt ID | P16070 |
Cellular Localization | Membrane. |
Function | Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. |
Post-translational Modifications | Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). Phosphorylated; activation of PKC results in the dephosphorylation of Ser-76 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
Domain | The lectin-like LINK domain is responsible for hyaluronan binding. |
Sequence Similarities | Contains 1 Link domain. |
Storage & Shipping
Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
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Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.