Anti-CD44 Rabbit Monoclonal Antibody (RMAB-0251455)
Cat. No.: RMAB-0251455
Category: Primary Antibodies
Research Area: Cancer Research, Immunology, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-CD44 Rabbit Monoclonal Antibody. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide within Human CD44 aa 65-75. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
Target Information
| Target Symbol | CD44 |
|---|---|
| Target Name | CD44 antigen |
| UniProt ID | P16070 |
| Function | Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. |
| Post-translational Modifications | Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). Phosphorylated; activation of PKC results in the dephosphorylation of Ser-76 (constitutive phosphorylation site), and the phosphorylation of Ser-672. |
| Domain | The lectin-like LINK domain is responsible for hyaluronan binding. |
| Sequence Similarities | Contains 1 Link domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
