Anti-CD45RA Antibody (RMAB-0250381)
Cat. No.: RMAB-0250381
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to CD45RA
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 4KB5 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Tissue, cells or virus corresponding to CD45RA. B cell lymphoma |
| Applications | IHC-P, Flow Cyt |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to CD45RA; Suitable for: IHC-P, Flow Cyt; Reacts with: Human |
Target Information
| Target Symbol | PTPRC |
|---|---|
| Target Name | Receptor-type tyrosine-protein phosphatase C |
| UniProt ID | P08575 |
| Cellular Localization | Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. |
| Involvement in Disease | Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positiveMultiple sclerosis |
| Post-translational Modifications | Heavily N- and O-glycosylated. |
| Domain | The first PTPase domain interacts with SKAP1. |
| Sequence Similarities | Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 0.05% BSA, 40% Glycerol (glycerin, glycerine), PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
