Anti-CD8 alpha Antibody (RMAB-0250413)
Cat. No.: RMAB-0250413
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to CD8 alpha
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EP1150Y |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human CD8 alpha aa 2 to the C-terminus (C terminal). |
| Applications | WB, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to CD8 alpha; Suitable for: WB, ICC/IF; Reacts with: Human |
Target Information
| Target Symbol | CD8A |
|---|---|
| Target Name | T-cell surface glycoprotein CD8 alpha chain |
| UniProt ID | P01732 |
| Cellular Localization | Secreted and Cell membrane. |
| Function | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
| Involvement in Disease | Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency). Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
| Post-translational Modifications | All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not. |
| Sequence Similarities | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
