Anti-Collagen I COL1A1 Rabbit Monoclonal Antibody (RMAB-0251509)
Cat. No.: RMAB-0251509
Category: Primary Antibodies
Research Area: Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Collagen I COL1A1 Rabbit Monoclonal Antibody. Tested in IHC, WB applications. This antibody reacts with Cow, Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | Flow Cyt, IHC |
Target Information
| Target Symbol | COL1A1 |
|---|---|
| Target Name | Collagen alpha-1(I) chain |
| UniProt ID | P08123 |
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Involvement in Disease | Ehlers-Danlos syndrome 7BOsteogenesis imperfecta 1Osteogenesis imperfecta 2Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular formOsteogenesis imperfecta 3Osteogenesis imperfecta 4A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7; 8)(p22; q13) with PLAG1. |
| Post-translational Modifications | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. |
| Domain | The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. |
| Sequence Similarities | Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
