Anti-CTNNA1 Antibody (RMAB-0250490)
Cat. No.: RMAB-0250490
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to CTNNA1
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 1G5 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human, Rat |
| Immunogen | Recombinant full length protein corresponding to Human CTNNA1. (A recombinant maltose binding protein fused to full length human alpha catenin). |
| Applications | WB, ICC/IF |
| Key Features | Mouse monoclonal to CTNNA1; Suitable for: WB, ICC/IF; Knockout validated; Reacts with: Rat, Human; Isotype: IgG1 |
Target Information
| Target Symbol | CTNNA1 |
|---|---|
| Target Name | Catenin alpha-1 |
| UniProt ID | P35221 |
| Cellular Localization | Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries. |
| Function | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
| Post-translational Modifications | Sumoylated. |
| Sequence Similarities | Belongs to the vinculin/alpha-catenin family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.02% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
