Anti-E2F4 Antibody (RMAB-0250535)
Cat. No.: RMAB-0250535
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to E2F4
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR8259 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human E2F4 aa 25-35. The exact sequence is proprietary. |
| Applications | WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to E2F4; Suitable for: WB, IHC-P; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | E2F4 |
|---|---|
| Target Name | Transcription factor E2F4 |
| UniProt ID | Q16254 |
| Cellular Localization | Nucleus. |
| Developmental Stage | Present in the growth-arrested state, its abundance does not change significantly as cells move into and through the cell cycle. |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB protein. |
| Post-translational Modifications | Differentially phosphorylated in vivo. |
| Sequence Similarities | Belongs to the E2F/DP family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
For research use only. Not for clinical use.
