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Anti-ERG Antibody (RMAB-0250549)

Cat. No.: RMAB-0250549

Category: Primary Antibodies

INQUIRY 100 μL Customer Size
Rabbit monoclonal to ERG

Product Features

Isotype IgG
Clonality Monoclonal
Host Species Rabbit
Clone Number EPR3863
Form Liquid
Purity Protein A purified
Species Reactivity Human
Immunogen Synthetic peptide.
Applications WB, IHC-P
Key Features Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to ERG; Suitable for: WB, IHC-P; Reacts with: Human

Target Information

Target Symbol ERG
Target Name Transcriptional regulator ERG
UniProt ID P11308
Cellular Localization Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Function Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Involvement in Disease Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21; 22)(q22; q12) with EWSR1.Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16; 21)(p11; q22) with FUS. Translocation t(X; 21)(q25-26; q22) with ELF4.
Sequence Similarities Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Storage & Shipping

Storage Buffer pH: 7.20; Preservative: 0.05% Sodium azide; Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
Storage & Shipping Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

For research use only. Not for clinical use.