Anti-ERG Antibody (RMAB-0250550)
Cat. No.: RMAB-0250550
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to ERG
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse, Human, Recombinant fragment |
| Immunogen | Synthetic peptide within Human ERG aa 45 to the C-terminus (C terminal). The exact sequence is proprietary. |
| Applications | Flow Cyt (Intra), ICC/IF, WB, IP, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to ERG; Suitable for: Flow Cyt (Intra), ICC/IF, WB, IP, IHC-P; Reacts with: Mouse, Human, Recombinant fragment |
Target Information
| Target Symbol | ERG |
|---|---|
| Target Name | Transcriptional regulator ERG |
| UniProt ID | P11308 |
| Cellular Localization | Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Function | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| Involvement in Disease | Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21; 22)(q22; q12) with EWSR1.Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16; 21)(p11; q22) with FUS. Translocation t(X; 21)(q25-26; q22) with ELF4. |
| Sequence Similarities | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
