Anti-ERG Antibody – Mouse IgG2b (Chimeric) (RMAB-0250552)
Cat. No.: RMAB-0250552
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Mouse monoclonal to ERG - Chimeric
Product Features
| Isotype | IgG2b |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to ERG - Chimeric; Suitable for: WB, IHC-P; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | ERG |
|---|---|
| Target Name | Transcriptional regulator ERG |
| UniProt ID | P11308 |
| Cellular Localization | Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Function | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| Involvement in Disease | Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21; 22)(q22; q12) with EWSR1.Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16; 21)(p11; q22) with FUS. Translocation t(X; 21)(q25-26; q22) with ELF4. |
| Sequence Similarities | Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
