Anti-ERK1 + ERK2 Antibody (RMAB-0250560)
Cat. No.: RMAB-0250560
Category: Primary Antibodies
INQUIRY
50 μL
Customer Size
Rabbit polyclonal to ERK1 + ERK2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Immunogen affinity purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide corresponding to Human ERK1 + ERK2 aa 317-339 (C terminal).Sequence: RIT VEEALAHPYL EQYYDPTDE |
| Applications | ICC, IHC-P, WB |
| Key Features | Rabbit polyclonal to ERK1 + ERK2; Suitable for: ICC, IHC-P, WB; Reacts with: Mouse, Rat, Human; Isotype: IgG |
Target Information
| Target Symbol | MAPK1 |
|---|---|
| Target Name | Mitogen-activated protein kinase 1 |
| UniProt ID | P28482 |
| Cellular Localization | Nucleus. |
| Function | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to aAAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. |
| Post-translational Modifications | Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187. |
| Domain | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | pH: 7.30; Preservative: 0.05% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.1% BSAphosphate buffered saline without Mg2+ and Ca2+. |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
