Anti-ERK2 Antibody - BSA and Azide free (Detector) (RMAB-0252053)
Cat. No.: RMAB-0252053
Category: Antibody Pair
INQUIRY
100 μg
1 mg
Rabbit monoclonal] to ERK2 - BSA and Azide free (Detector)
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR26587-54 |
| Form | Liquid |
| Species Reactivity | Mouse, Rat, Human |
| Applications | Sandwich ELISA |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal] to ERK2 - BSA and Azide free (Detector); Suitable for: Sandwich ELISA; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | MAPK1 |
|---|---|
| Target Name | Mitogen-activated protein kinase 1 |
| UniProt ID | P28482 |
| Cellular Localization | Nucleus. |
| Function | Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to aAAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. |
| Post-translational Modifications | Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-187. |
| Domain | The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Constituent: 100% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C. |
For research use only. Not for clinical use.
