Anti-Frizzled 8 Antibody (RMAB-0250606)
Cat. No.: RMAB-0250606
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Frizzled 8
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR7308(2) |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human Frizzled 8 aa 65-75. The exact sequence is proprietary. |
| Applications | WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Frizzled 8; Suitable for: WB, IHC-P; Reacts with: Human |
Target Information
| Target Symbol | FZD8 |
|---|---|
| Target Name | Frizzled-8 |
| UniProt ID | Q9H461 |
| Cellular Localization | Membrane. Golgi apparatus. Cell membrane. Colocalizes with GOPC at the Golgi apparatus. |
| Epitope | HeLa and Jurkat lysates; Human endometrial carcinoma tissue. |
| Function | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Post-translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Domain | The PDZ-binding motif mediates interaction with GOPC.Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.The FZ domain is involved in binding with Wnt ligands. |
| Sequence Similarities | Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. |
Storage & Shipping
| Storage Buffer | Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at -20°C. |
For research use only. Not for clinical use.
