Anti-GATA4 Rabbit Monoclonal Antibody

Anti-GATA4 Rabbit Monoclonal Antibody (RMAB-0251480)

Cat. No.: RMAB-0251480

Category: Primary Antibodies

Research Area: Cardiovascular, Cancer Research, Stem Cells, Epigenetics

INQUIRY 100 μL Customer Size

Anti-GATA4 Rabbit Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human, Mouse, Rat.

Target Symbol	GATA4
Target Name	Transcription factor GATA-4
UniProt ID	P43694
Function	Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24169). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:281228). Required during testicular development (PubMed:2122346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
Involvement in Disease	Atrial septal defect 2Ventricular septal defect 1Tetralogy of FallotAtrioventricular septal defect 4Testicular anomalies with or without congenital heart diseaseGATA4 mutations can predispose to dilated cardiomyopathy (CMD), a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Post-translational Modifications	Methylation at Lys-3 attenuates transcriptional activity.
Sequence Similarities	Contains 2 GATA-type zinc fingers.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.