Anti-GFAP Antibody (RMAB-0250628)
Cat. No.: RMAB-0250628
Category: Primary Antibodies
INQUIRY
50 μL
Customer Size
Rabbit polyclonal to GFAP
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Whole antiserum |
| Species Reactivity | Mouse, Rat |
| Immunogen | Recombinant full length protein corresponding to Human GFAP. Isotype 1 expressed in and purified from E. coli. |
| Applications | IHC (PFA fixed), ICC/IF, IP, WB, IHC-P |
| Key Features | Rabbit polyclonal to GFAP; Suitable for: IHC (PFA fixed), ICC/IF, IP, WB, IHC-P; Reacts with: Mouse, Rat; Isotype: IgG |
Target Information
| Target Symbol | GFAP |
|---|---|
| Target Name | Glial fibrillary acidic protein |
| UniProt ID | P14136 |
| Cellular Localization | Cytoplasm. Associated with intermediate filaments. |
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Involvement in Disease | Defects in GFAP are a cause of Alexander disease (ALEXD). Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. |
| Post-translational Modifications | Phosphorylated by PKN1. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.03% Sodium azide |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
