Anti-GFAP Antibody (RMAB-0250629)
Cat. No.: RMAB-0250629
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Mouse monoclonal to GFAP
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 2A5 |
| Form | Liquid |
| Purity | Tissue culture supernatant |
| Species Reactivity | Mouse, Rat, Human, Pig |
| Immunogen | Full length native protein (purified) corresponding to Pig GFAP. A preparation of purified pig spinal cord GFAP. |
| Applications | IHC-FrFl, WB, IHC-P, ICC/IF |
| Key Features | Mouse monoclonal to GFAP; Suitable for: IHC-FrFl, WB, IHC-P, ICC/IF; Reacts with: Mouse, Rat, Human, Pig; Isotype: IgG1 |
Target Information
| Target Symbol | GFAP |
|---|---|
| Target Name | Glial fibrillary acidic protein |
| UniProt ID | P14136 |
| Cellular Localization | Cytoplasm. Associated with intermediate filaments. |
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Involvement in Disease | Defects in GFAP are a cause of Alexander disease (ALEXD). Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. |
| Post-translational Modifications | Phosphorylated by PKN1. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.065% Sodium azide; Constituent: Tissue culture supernatantConcentrated Tissue Culture Supernatant |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
