Anti-Glypican 3 Antibody (RMAB-0250653)
Cat. No.: RMAB-0250653
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Rabbit polyclonal to Glypican 3
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Purity | Immunogen affinity purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human Glypican 3 aa 1-2 conjugated to keyhole limpet haemocyanin.(Peptide available as ab11376) |
| Applications | ICC/IF, WB |
| Key Features | Rabbit polyclonal to Glypican 3; Suitable for: ICC/IF, WB; Knockout validated; Reacts with: Human; Isotype: IgG |
Target Information
| Target Symbol | GPC3 |
|---|---|
| Target Name | Glypican-3 |
| UniProt ID | P51654 |
| Cellular Localization | Cell membrane and Secreted > extracellular space. |
| Function | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. |
| Involvement in Disease | Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. |
| Sequence Similarities | Belongs to the glypican family. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituent: PBSBatches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
