Anti-Glypican 3 Antibody (RMAB-0250656)
Cat. No.: RMAB-0250656
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Glypican 3
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | rGPC3/863 |
| Form | Liquid |
| Purity | Protein A/G purified |
| Species Reactivity | Human |
| Immunogen | Recombinant full length protein corresponding to Human Glypican 3. |
| Applications | IHC-P, Protein Array, ICC |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to Glypican 3; Suitable for: IHC-P, Protein Array, ICC; Reacts with: Human |
Target Information
| Target Symbol | GPC3 |
|---|---|
| Target Name | Glypican-3 |
| UniProt ID | P51654 |
| Cellular Localization | Cell membrane and Secreted > extracellular space. |
| Function | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. |
| Involvement in Disease | Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. |
| Sequence Similarities | Belongs to the glypican family. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.05% Sodium azide; Constituents: 99% PBS, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
