Anti-Glypican 3 Antibody (RMAB-0250657)
Cat. No.: RMAB-0250657
Category: Primary Antibodies
INQUIRY
1 mL
500 μL
Rabbit monoclonal to Glypican 3
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | SP86 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human Glypican 3 aa 5 to the C-terminus (C terminal). The exact sequence is proprietary. |
| Applications | ICC/IF, Flow Cyt, WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Glypican 3; Suitable for: ICC/IF, Flow Cyt, WB, IHC-P; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | GPC3 |
|---|---|
| Target Name | Glypican-3 |
| UniProt ID | P51654 |
| Cellular Localization | Cell membrane and Secreted > extracellular space. |
| Function | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. |
| Involvement in Disease | Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. |
| Sequence Similarities | Belongs to the glypican family. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.1% Sodium azide; Constituents: 1% BSA, PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
For research use only. Not for clinical use.
